iSyntaxToTIFF

Requirements

• iSyntaxToTIFF release package for Windows or Linux.
• Philips Pathology SDK obtained directly from Philips and configured in the app.
• Philips .isyntax whole-slide image files.

SDK package

As of June 2026, the Philips Pathology SDK can be obtained from the Philips portal by searching for PathologySDK and downloading PathologySDK_2.0-L1_Packages.

Main features

• Conversion from Philips .isyntax to pyramidal RGB .ome.tif.
• SDK setup from a ZIP file or from an extracted SDK folder.
• SDK import test from the GUI.
• Thumbnail preview before conversion.
• Optional output folder selection.
• CSV conversion log for each batch run.
• Windows and Linux build workflows.

Recommended use

• Select or prepare the Philips Pathology SDK once from the File menu.
• Run Test SDK before conversion.
• Use Deflate lossless compression for maximum practical fidelity.
• Use display view for brightfield visual workflows such as H&E and IHC.
• If no output folder is selected, outputs are saved beside each input file.

First-time workflow

1. Download and extract the iSyntaxToTIFF release package for your operating system.
2. Run iSyntaxToTIFF.
3. Go to File > Select / Prepare SDK ZIP or folder.
4. Select the Philips Pathology SDK ZIP or extracted SDK folder.
5. Run File > Test SDK.
6. On Windows, if required, run File > Run SDK installer.
7. Add .isyntax files and convert them to .ome.tif.

Outputs

For each converted file, the app creates:

• A pyramidal RGB OME-TIFF file: image_name.ome.tif.
• OME metadata including physical pixel size when exposed by OpenPhi.
• Internal tiled pyramid levels suitable for whole-slide viewers.
• A CSV conversion log documenting success, errors and output paths.

Compression

• Deflate lossless: recommended default.
• JPEG: optional smaller lossy output with quality control.
• Uncompressed: optional but produces very large files.

Deflate is lossless with respect to the rendered RGB image returned by OpenPhi.

OpenPhi-based reading

The app uses OpenPhi to open Philips iSyntax files, read metadata, generate thumbnails, and extract image regions. iSyntaxToTIFF then writes the rendered RGB data as pyramidal OME-TIFF.

Notes and limitations

• Designed mainly for brightfield visual workflows such as H&E and IHC.
• The output is a rendered RGB representation, not a raw scanner data export.
• Raw multichannel fluorescence information or quantitative intensity preservation should be validated independently.
• The Philips Pathology SDK is required separately and is subject to Philips' own license terms.

Supported SDK targets

• Windows: Philips Pathology SDK Windows Python 3.7 research package.
• Linux: Philips Pathology SDK Ubuntu 20.04 Python 3.8 research package.